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Liquid. Bioavailable.
Clinically-Backed
Methylfolate Benefits.

We take L-Methylfolate science to another level because restoring your neurochemistry requires absolute precision.

SHOW ME THE RESULTS
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Our Methylfolate Research Findings

Bioavailability & Cognitive Function

Optimized Methylfolate is clinically shown to bypass common gene mutations to fuel brain health.1-4

Up to 50% of the population has the MTHFR gene mutation, limiting their ability to convert standard folic acid into a usable form. Our Methylfolate is pre-methylated, ensuring it crosses the blood-brain barrier to support neurotransmitter synthesis and provide other Methylfolate benefits effectively.

Standard
Folic Acid

Diet + Standard

34%

of folate
requirements utilized
by brain

Optimized
Methylfolate

Diet + Methylfolate

92%

of folate
requirements utilized
by brain

Bioavailability

According to Methylfolate research, key nutrients in Neupril have been shown to be quickly and easily absorbed into the body.1

Methylfolate absorption over 480 minutes Line chart comparing placebo and Neupril Methyl-B12 methylfolate levels over time. Placebo Neupril Methyl-B12 0 7 14 21 28 0 60 120 180 240 300 360 420 480 MINUTES METHYLFOLATE (ng/mL)

Nutrient Levels

Neupril Methyl-B12 improves key nutrient levels within 3 months.1

33%

increase in Vitamin B12 levels1

Vitamin B12 levels at month 0 and month 3 Bar chart comparing Placebo and Neupril Methyl-B12 Vitamin B12 levels. Placebo Neupril Methyl-B12 200 300 400 500 600 700 VITAMIN B12 (PG/ML) MONTH 0 MONTH 3 ↑33%

1. Based on a 12-week double-blind, placebo-controlled study of 45 participants supplementing with 1000mcg Methylcobalamin daily. Individual results may vary.

Cellular Energy

Neupril Methylfolate is clinically shown to boost ATP production.1‑3

Unlike standard folic acid, Neupril bypasses the MTHFR gene mutation, directly fueling the methylation cycle needed for mitochondrial efficiency.

Over 10x

Average increase in mitochondrial efficiency and ATP synthesis1‑3

Control Neupril Methylfolate
ATP Energy Molecule
Inactive Mitochondria
Active Mitochondria
Cellular Waste
Red supplement ingredient powder close-up

Third Party Tested

Besides being backed by sound L-Methylfolate science, Neupril L-Methylfolate Drops are routinely third-party tested to verify potency, purity, and safety, ensuring every bottle matches the exact levels listed on the label.

Each batch is screened for vitamins, minerals, and potential contaminants so you can experience Methylfolate benefits while knowing exactly what you’re putting in your body.

Our drops are free from:

  • Pesticides
  • Heavy metals
  • Environmental contaminants
  • Microbial contaminants.

Certifications

Neupril is manufactured in NSF, GMP-certified, and FDA-registered facilities in the United States. We prioritize high standards at every step, from sourcing to bottling, to ensure consistent quality you can trust.

Red supplement ingredient powder in a petri dish
Neupril dropper bottles with berries

Free of Allergens

We don’t use wheat, dairy, egg, or peanut ingredients in our formula. Our manufacturing facilities follow strict allergen controls and validated cleaning protocols to minimize any chance of cross-contamination. We test for common allergens:

  • Gluten (Wheat, Rye, Barley)
  • Milk
  • Egg
  • Peanut

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