✨ Limited time sale! Save over 50% ✨

FAQs

Got questions? We've got answers.

General Questions

Neupril is a premium liquid dietary supplement featuring bioactive L-Methylfolate (5-MTHF) combined with Methylcobalamin (Methyl B12). It is designed to support cellular methylation, brain health, sustained energy, balanced mood, and cognitive clarity in a rapid-absorption liquid format.
Take your recommended dose once daily using the calibrated dropper. You can place the drops under your tongue (sublingually) for optimal absorption, or mix them into water, juice, or a smoothie. We recommend taking Neupril in the morning with breakfast.
L-Methylfolate is the active, body-ready form of Vitamin B9. Unlike synthetic folic acid, it bypasses genetic metabolic bottlenecks to directly support neurotransmitter synthesis (serotonin, dopamine, norepinephrine), homocysteine regulation, cellular detox, cardiovascular vitality, and energy production.
If you experience brain fog, persistent fatigue, mood swings, or carry the common MTHFR genetic mutation (C677T or A1298C), your body may struggle to convert synthetic folic acid. Supplementing with active methylfolate provides immediate, bioavailable folate.
Neupril Adults delivers a clinical 15 mg bio-equivalent strength tailored for adult methylation, mood, and cognitive performance. Neupril Kids is calibrated with gentle micro-dosages tailored to growing children (ages 1–3, 4–13, and teens) with a child-friendly organic berry taste.
No. Methylfolate is active Vitamin B9 (5-MTHF) and Methylcobalamin is active Vitamin B12. They work synergistically in the folate-methionine cycle to convert homocysteine into methionine. Combining both prevents folate trapping and ensures balanced cellular methylation.
Many individuals report noticeable improvements in mental clarity, focus, and energy within 1 to 2 weeks of daily use. Cumulative cellular and mood benefits typically solidify over 30 to 60 days of consistent supplementation.
Neupril has a naturally pleasant, mild taste with subtle organic berry notes. It contains no artificial sweeteners, no chemical dyes, and leaves no bitter or metallic aftertaste.
We strongly recommend taking Neupril in the morning or early afternoon. Because active B-vitamins promote natural cellular energy and alertness, taking them late in the evening may interfere with sleep.
We offer a 30-day satisfaction guarantee for first-time orders. Simply visit our Make a Return page with your Order Number and Email, or contact our support team at support@neupril.com to initiate a hassle-free refund or exchange.
If you or your child are not completely satisfied with Neupril within 30 days of receiving your package, reach out to our customer care team for a full product refund.
You can reach us through our Contact Us page, email us directly at support@neupril.com, or submit your inquiry through our website contact form. Our support team typically responds within 24 hours.

Shipping & Delivery

Standard US orders are processed within 24–48 hours and typically arrive within 3 to 5 business days. You will receive an automated tracking link via email as soon as your package ships.
Orders are processed quickly by our fulfillment warehouse. If you need to modify or cancel your order, please email support@neupril.com within 1 hour of placing it.
You can check your shipment status anytime using our online Order Tracking tool by entering your Order Number (e.g., NP-XXXXXX) and email address.
Please email support@neupril.com immediately with your Order Number and corrected shipping address. If the order has not yet left our warehouse, we will update the destination for you.
First, check the live carrier tracking link provided in your shipping confirmation email. If the shipment is stuck for more than 48 hours or marked delivered without arrival, contact support@neupril.com and we will resolve it promptly.
We currently ship across all 50 US states, as well as select international destinations including Canada, the UK, Australia, and New Zealand.

Ingredients

Neupril contains bioactive L-Methylfolate (calcium L-5-methyltetrahydrofolate), Methylcobalamin (active Vitamin B12), USP reverse osmosis purified water, organic vegetable glycerin, and natural organic berry flavor. Zero artificial additives.
We source pharmaceutical-grade, clinically researched raw ingredients from certified global manufacturers adhering to strict cGMP and ISO quality standards.
Yes. Neupril is 100% vegan, non-GMO, gluten-free, dairy-free, soy-free, egg-free, nut-free, and contains no synthetic preservatives, artificial sweeteners, or dyes.
Neupril provides targeted methylation cofactors (active B9 + B12). You can continue taking your general multivitamin alongside Neupril, provided you avoid excessive doses of synthetic folic acid.
California Proposition 65 requires warnings for products containing chemicals known to the state. Neupril meets rigorous safety testing standards and is verified free of unsafe contaminants or heavy metals.
Yes. Every production batch is independently tested by accredited third-party laboratories for potency, purity, heavy metals (lead, arsenic, cadmium, mercury), and microbial safety.
While not acutely harmful, synthetic folic acid can bind to folate receptors and block active methylfolate uptake. For individuals with MTHFR mutations, choosing pure methylfolate alone is generally recommended.
No. Folic acid is an artificial oxidized compound requiring multiple liver enzyme steps to convert. L-Methylfolate (5-MTHF) is the biologically active form that passes directly into cells and across the blood-brain barrier.
Calcium L-5-Methyltetrahydrofolate (L-5-MTHF) is widely recognized as the most bioavailable, stable, and metabolically active form of supplemental folate.
Yes. Neupril Adults is dosed for adult physiology, and Neupril Kids provides precise, pediatric-appropriate dropper micro-dosages safe for children ages 1 and above.
Vitamin B12 is the crucial cofactor for the enzyme methionine synthase. Taking active B12 together with methylfolate ensures seamless homocysteine recycling and prevents the 'methyl trap'.
Methylcobalamin is the natural, bioactive coenzyme form of B12. Unlike synthetic cyanocobalamin, it does not require liver decyanation and is ready for immediate cellular use.

Product

Yes. Consistent daily supplementation is recommended to sustain optimal methylation pathways, balanced mood chemistry, and steady cognitive energy.
Refrigeration is not mandatory, but storing in a cool, dry place away from direct sunlight—or chilling after opening—maintains peak freshness and flavor.
Yes, every batch undergoes comprehensive ICP-MS testing for heavy metals (lead, arsenic, cadmium, mercury) to ensure compliance with strict purity thresholds.
Neupril is manufactured in the USA inside FDA-registered, cGMP-certified facilities adhering to rigorous quality standards from raw ingredient verification to final bottling.
While methylfolate is a natural B-vitamin, please consult your physician or pharmacist before introducing any new supplement if you take medications such as anticonvulsants or methotrexate.
Active folate is essential for fetal neural development and maternal health. However, you should always consult your OB/GYN or midwife regarding exact dosages during pregnancy and nursing.
For adults, 1 full dropper daily provides clinical support. For children, dosage is guided by age brackets (1–3 years: 2 drops; 4–13 years: 4 drops; teens: 6 drops) as indicated on the bottle label.
MTHFR (Methylenetetrahydrofolate Reductase) is a key gene and enzyme responsible for converting inactive dietary folate into active L-methylfolate. Genetic polymorphisms in MTHFR can decrease folate conversion efficiency by up to 70%.
Yes! Active L-methylfolate is universally bioavailable and easier for anyone's body to absorb without expending metabolic energy on chemical conversion.
For Neupril Adults, 1 full dropper (1 mL) is the standard daily serving. For Neupril Kids, individual calibrated drops (2–6 drops based on child's age) are used.
Our support and product guidance team is happy to help. Reach out to us anytime at support@neupril.com or through our Contact page.